Reports

NTP Reports

NTP considered the KCs of carcinogens to organize and evaluate mechanistic data in the following assessments:

Monograph on Antimony Trioxide, Report on Carcinogens, October 2018. Office of the Report on carcinogens, National Toxicology Program, National Institute of Environmental Health Sciences, U.S. Department of Health and Human Services.

Draft Monograph on Night Shift Work and Light at Night. Report on Carcinogens, August 24, 2018. Office of the Report on carcinogens, National Toxicology Program, National Institute of Environmental Health Sciences, U.S. Department of Health and Human Services.

NTP described a role for KCs of carcinogens in recent Annual Reports.

National Toxicology Annual Report for 2019. Describes the NICEATM Converging on Cancer Workshop on pages 10 and 32.

National Toxicology Annual Report for 2018. Tox21 assay target mapping and Bayesian network modeling Warren Casey, Nicole Kleinstreuer: “NICEATM is mapping Tox21/ToxCast assay targets to known modes of action for developmental toxicity, acute toxicity, and carcinogenicity. Carcinogenicity assay target mapping is informed by the key characteristics of carcinogens and the hallmarks of cancer. Mapped assays are being combined with in silico features to build Bayesian network models to provide probabilistic predictions of chemical hazard. A manuscript describing this approach is being drafted.”


 

OEHHA Reports

OEHHA used the KCs for carcinogens to organize and evaluate mechanistic data for the following chemicals, in the documents provided in the associated links:

Evidence on the Carcinogenicity of Coumarin. Proposition 65. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. August 2017.

Evidence on the Carcinogenicity of Gentian Violet. Proposition 65. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. January 2019 Update.

Evidence on the Carcinogenicity of N-Nitrosohexamethylemeimine. Proposition 65. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. January 2019 Update.

Evidence on the Carcinogenicity of Acetaminophen. Proposition 65. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. September 2019 Update.


 

IARC Reports

IARC describes the use the KCs of carcinogens to organize and evaluate mechanistic data in the revised Preamble (Jan, 2019) to the Monographs:

Preamble. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Lyons, France, 2019. Amended January, 2019.

IARC used the KCs of carcinogens to organize and evaluate mechanistic data in all their assessments from Volume 112 onwards. These include:

Night Shift Work. IARC Monographs on the Identification of Carcinogenic Hazards to Humans Volume 124. Lyons, France, 2020. Infographic

Some Nitrobenzenes and Other Industrial Chemicals. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 123. Lyons, France, 2020.

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